宿主抗病毒感染与免疫生物学团队

科研成果

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  英文论文(2013–2019.12)

  2019

  (1)Bai XW*, Bao HF, Li PH, Ma XQ, Sun P, Bai QF, Zhang M, Yuan H, Chen DD, Li K, Chen YL, Cao YM, Fu YF, Zhang J, Li D, Lu ZJ, Liu ZX*, Luo JX. Engineering responses to amino acid substitutions in the vp0- and VP3-coding regions of Panasia-1 strains of foot-and-mouth disease virus serotype O. Journal of Virology, 2019, 93(7): e02278-18

  (2)Cao Y, Li K, Wang S, Fu Y, Sun P, Li P, Bai X, Zhang J, Ma X, Xing X, Zhou S, Bao H, Li D, Chen Y, Li Z, Lu Z, Liu Z. Implication of broadly neutralizing bovine monoclonal antibodies in the development of an enzyme-linked immunosorbent assay for detecting neutralizing antibodies against foot-and-mouth disease virus serotype O J Clinical Microbiol, 2019, 57(12): e01030-19

  (3)Li K, Wang S, Cao Y, Bao H, Li P, Sun P, Bai X, Fu Y, Ma X, Zhang J, Li D, Chen Y, Liu X, An F, Wu F, Lu Z, Liu Z. Development of foot-and-mouth disease virus-neutralizing monoclonal antibodies derived from plasmablasts of infected cattle and their germline gene usage. Front Immunol, 2019, 10: 2870

  (4)Xie Y, Li H, Qi X, Ma Y, Yang B, Zhang S, Chang H, Yin X, Li Z. Immunogenicity and protective efficacy of a novel foot-and-mouth disease virus empty-capsid-like particle with improved acid stability. Vaccine, 2019, 37: 2016–2025

  (5)Ping Du, Ronghuan Liu, Shiqi Sun, Hu Dong, Ruibo Zhao, Ruikang Tang, Jianwu Dai,  Hong Yin, Jianxun Luo, Zaixin Liu, Huichen Guo. Biomineralization improves the thermostability of foot-and-mouth disease virus-like particles and the protective immune response induced. Nanoscale,2019:DOI: 10.1039/c9nr05549e

  (6)Xingqi Zou, Yuanyuan Zhu, Huifang Bao, Xiaoyu Guo, Pu Sun,  Zaixin Liu, Peter W. Mason, Lu Xu, Cui Li, Qianyi Zhang, Qin Wang,  Hongfei Zhu, Qizu Zhao. Recombination of host cell mRNA with the Asia 1 foot‑and‑mouth disease virus genome in cell suspension culture. Archives of Virology (2019) 164:41–50

  2018

  (1)Bai WJ, Wang ZJ, Sun P, Zhang J, Bao HF, Cao YM, Chang YY, Liu ZX, Li D*, Lu ZJ*. The molecular characteristic analysis of PRRSV GSWW/2015 strain and its pathogenicity to pigs. BMC Veterinary Research, 2018, 14(1): 240

  (2)Cao YM*, Zhou W, Xing XC, Zhang J, Fu YF, Li K, Sun P, Li PH, Bai XW, Ma XQ, Bao HF, Li D, Chen YL, Lu ZJ*, Liu ZX*. Indirect ELISA using a multi-epitope recombinant protein to detect antibodies against foot-and-mouth disease virus serotype O in pigs. Journal of Virological Methods, 2018, 262: 26–31

  (3)Sun P#, Zhang S#, Qin X#, Chang X, Cui X, Li H, Zhang S, Gao H, Wang P, Zhang Z*, Luo J, Li Z*. Foot-and-mouth disease virus capsid protein VP2 activates the cellular EIF2S1-ATF4 pathway and induces autophagy via HSPB1. Autophagy, 2018, 14(2): 336–346

  2017

  (1)Cao Y*, Li D, Fu Y, Bai Q, Chen Y, Bai X, Jing Z, Sun P, Bao H, Li P, Zhang J, Ma X, Lu Z*, Liu Z*. Rational design and efficacy of a multi-epitope recombinant protein vaccine against foot-and-mouth disease virus serotype A in pigs. Antiviral Research, 2017, 140: 133–141

  (2)Du P, Sun S, Dong J, Zhi X, Chang Y, Teng Z, Guo H*, Liu Z*. Purification of foot-and-mouth disease virus by heparin as ligand for certain strains. J Chromatogr B Analyt Technol Biomed Life Sci. 2017, 1049-1050: 16–23

  (3)Fu YF, Li PH, Cao YM, WangN, Sun P, Shi Q, Ji XC, Bao HF, Li D, Chen YL, Bai XW, Ma XQ, Zhang J, Lu ZJ*,Liu ZX*. Development of a Blocking ELISA Using a Monoclonal Antibody to aDominant Epitope in Non-Structural Protein 3A of Foot-and-Mouth Disease Virus,as a Matching Test for a Negative-Marker Vaccine, PLoS ONE, 2017, 12(1): e0170560

  (4)Li K#, Bao HF#, Wei GY, Cao YM, Li D, Li PH, Zhang J, Chen YL, Fu YF, Sun P, Bai XW, Ma XQ, Lu ZJ*, Liu ZX*. Molecular Vaccine Prepared by Fusion of XCL1 to Multi-Epitopes Protein of Foot-and-Mouth Disease Virus enhances Specific Humoral Immune Response in Cattle. Applied Microbiology and Biotechnology, 2017, 101(21): 7889–7900

  (5)Li K, Wei GY, Cao YM, Li D, Li PH, Zhang J, Bao HF, Chen YL, Fu YF, Sun P, Bai XW, Ma XQ, Lu ZJ*, Liu ZX*. The identification and distribution of cattle XCR1 and XCL1 among peripheral blood cells: new insights into the design of dendritic cells targeted veterinary vaccine. PLoS ONE, 2017, 12(1): e0170575

  (6)Zhang J, Sun P, Gan L, Bai WJ, Wang ZJ, Li D, Cao YM, Fu YF, Li PH, Bai XW, Ma XQ, Bao HF, Chen YL, Liu ZX*, Lu ZJ*. Genome-wide analysis of long noncoding RNA profiling in PRRSV-infected PAM cells by RNA sequencing. Sci Rep, 2017, 7(1): 4952

  2016

  (1)Yimei Cao, Zengjun Lu, Zaixin Liu. Foot-and-mouth disease vaccines: progress and problems. Expert Rev Vaccines. 2016, 15(6): 783–789

  (2)Fu Y, Zhu Z, Chang H, Liu Z, Liu J, Chen H. Comparative transcriptome analyses indicate enhanced cellular protection against FMDV in PK15 cells pretreated with IFN-γ. Gene, 2016, 586(2): 206–215

  (3)Xueqing Ma, Pinghua Li, Pu Sun, Zengjun Lu, Huifang Bao, Xingwen Bai, Yuanfang Fu, Yimei Cao, Dong Li, Yingli Chen, Zilin Qiao, Zaixin liu. Genome sequence of foot-and-mouth disease virus outside the 3A region is also responsible for virus replication in bovine cells. Virus Res. 2016, 220: 64–69

  (4)White GS, Symmes K, Sun P, Fang Y, Garcia S, Steiner C, Smith K, Reisen WK, Coffey LL. Reemergence of St. Louis Encephalitis Virus, California, 2015. Emerg Infect Dis, 2016, 22(12): 2185–2188

  (5)Zhu N, Zhang J, Qin X, Miao R, Du Y, Yang J. ZIP restores estrogen receptor expression and response to Tamoxifen in estrogen receptor negative tumors. Biochemical & Biophysical Research Communications, 2016, 480(4): 570–573

  2015

  (1)Shaodong Jiang, Xingwen Bai, Pinghua Li, Meng Zhang, Huifang Bao, Pu Sun, Zengjun Lu, Yimei Cao, Yingli Chen, Dong Li, Yuanfang Fu, Zaixin liu. Influence of Foot-and-Mouth Disease Virus O/CHN/Mya98/33-P Strain Leader Protein on Viral Replication and Host Innate Immunity. Viral Immunol. 2015, 28(7): 360–366

  (2)Xueqing Ma, Pinghua Li, Pu Sun, Xingwen Bai, Huifang Bao, Zengjun Lu, Yuanfang Fu, Yimei Cao, Dong Li, Yingli Chen, Zilin Qiao, Zaixin Liu. Construction and characterization of 3A-epitope-tagged foot-and-mouth disease virus. Infect Genet Evol. 2015, 31: 17–24

  2014

  (1)Xingwen Bai, Huifang Bao, Pinghua Li, Wei Wei, Meng Zhang, Pu Sun, Yimei Cao, Zengjun Lu, Yuanfang Fu, Baoxia Xie, Yingli Chen, Dong Li, Jianxun Luo, Zaixin Liu. Effects of two amino acid substitutions in the capsid proteins on the interaction of two cell-adapted PanAsia-1 strains of foot-and-mouth disease virus serotype O with heparan sulfate receptor. Virol J. 2014, 11: 132 

  (2)Yimei Cao. Adjuvants for foot-and-mouth disease virus vaccines: recent progress. Expert Rev Vaccines. 2014, 13(11): 1377–1385

  (3)Yimei Cao, Zengjun Lu, Dong Li, Pengju Fan, Pu Sun, Huifang Bao, Yuanfang Fu, Pinghua Li, Xingwen Bai, Yingli Chen, Baoxia Xie, Zaixin Liu. Evaluation of cross-protection against three topotypes of serotype O foot-and-mouth disease virus in pigs vaccinated with multi-epitope protein vaccine incorporated with poly(I:C). Vet Microbiol. 2014, 168(2-4): 294–301

  (4)Yanyan Chang, Yongxi Dou, Huifang Bao, Xuenong Luo, Xuerong Liu, Kebin Mu, Zaixin Liu, Xiangtao Liu, Xuepeng Cai. Multiple microRNAs targeted to internal ribosome entry site against foot-and-mouth disease virus infection in vitro and in vivo. Virology J. 2014, 11: 1

  (5)Yuanfan Fu, Zengjun Lu, Pinghua Li, Yimei Cao, Pu Sun, Meina Tian, Na Wang, Huifang Bao, Xingwen Bai, Dong Li, Yingli Chen, Zaixin Liu. Development of a blocking ELISA based on a monoclonal antibody against a predominant epitope in non-structural protein 3B2 of foot-and-mouth disease virus for differentiating infected from vaccinated animals. PLoS One. 2014, 9(11): e111737

  (6)Pinghua Li, Zengjun Lu, Xingwen Bai, Dong Li, Pu Sun, Huifang Bao, Yuanfang Fu, Yimei Cao, Yingli Chen, Baoxia Xie, Hong Yin, Zaixin Liu. Evaluation of a 3A-truncated foot-and-mouth disease virus in pigs for its potential as a marker vaccine. Vet Res. 2014, 45: 51

  (7)Shijie Ma, Kun Li, Xinsheng Li, Xiaoqing Guo, Pengfei Fu, Mingfan Yang, Hongying Chen. Expression of bioactive porcine interferon-alpha in Lactobacillus casei. World J Microbiol Biotechnol. 2014, 30: 2379–2386

  (8)Xueqing Ma, Pinghua Li, Xingwen Bai, Pu Sun, Huifang Bao, Zengjun Lu, Yimei Cao, Dong Li, Yingli Chen, Zilin Qiao, Zaixin Liu. Sequences outside that of residues 93-102 of 3A protein can contribute to the ability of foot-and-mouth disease virus (FMDV) to replicate in bovine-derived cells. Virus Res. 2014, 191: 161–171

  (9)Chunxue Zhou, Dong Li, Yingli Chen, Zengjun Lu, Pu Sun, Yimei Cao, Huifang Bao, Yuanfang Fu, Pinghua Li, Xingwen Bai, Baoxia Xie, Zaixin Liu. Resiquimod and polyinosinic-polycytidylic acid formulation with aluminum hydroxide as an adjuvant for foot-and-mouth disease vaccine. BMC Vet Res. 2014, 10: 2

  2013

  (1)Yimei Cao, Zengjun Lu, Yanli Li, Pu Sun, Dong Li, Pinghua Li, Xingwen Bai, Yuanfang Fu, Huifang Bao, Chunxue Zhou, Baoxia Xie, Yingli Chen, Zaixin Liu. Poly(I:C) combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs. Antiviral Res. 2013, 97(2): 145–153

  (2)Dong Li, Chunxue Zhou, Daliang She, Ping hua Li, Pu Sun, Xingwen Bai, Yingli Chen, Baoxia Xie, Zaixin Liu. The comparison of the efficacy of swine FMD vaccine emulsified with oil adjuvant of ISA 201 VG or ISA 206 VG. J Biosci Med. 2013, 1: 22–25

  中文核心期刊、第一单位论文(2013–2019.12)

  (1)李平花, 马雪青, 袁红, 袁子文, 孙普, 白兴文, 卢曾军, 刘在新. 3A 蛋白104–115 位氨基酸缺失口蹄疫A 型标记病毒的构建. 微生物学报, 2019, 59(5): 907–915

  (2)曹轶梅, 王兴凯, 王省, 李坤, 付元芳, 李冬, 卢曾军, 刘在新. 三种大肠杆菌表达的口蹄疫病毒A 型多表位蛋白对猪的免疫原性比较. 微生物学报, 2019, 59(4): 711–718

  (3)陈冬冬, 白兴文, 宫晓华, 包慧芳, 李平花, 李冬, 付元芳, 白启峰, 袁红, 孙普, 马雪青, 曹轶梅, 陈应理, 卢曾军, 刘在新. VP3 G–H 环中氨基酸突变对O 型口蹄疫病毒生物学特性的影响. 微生物学报, 2019, 59(7): 1285–1294

  (4)汪肖肖, 孙普, 王省, 谯雨, 卢曾军, 刘在新. 口蹄疫表位疫苗的研究进展. 中国兽医科学, 2019, 49(04): 499–505

  (5)汪肖肖, 孙普, 贾怀杰, 李冬, 付元芳, 陈应理, 曹轶梅, 景志忠, 白兴文, 卢曾军, 刘在新. A 型口蹄疫病毒衣壳蛋白主要抗原表位区的原核表达及免疫效果分析. 中国兽医科学, 2019, 49(10): 1207–1215

  (6)谯雨, 王治家, 张婧, 孙普, 白兴文, 李坤, 包慧芳, 曹轶梅, 李平花, 李冬, 刘在新, 卢曾军. 两株PRRSV NSP2 不同位置缺失基因工程病毒的生物学特性分析. 中国兽医科学, 2019, 49(09): 1073–1081

  (7)王省, 李坤, 卢曾军, 刘在新, 李冬, 包慧芳, 李平花, 孙普, 白兴文, 陈应理, 付元芳, 张婧, 马雪青, 曹轶梅. 口蹄疫病毒VP2 蛋白特异性单克隆工程抗体的表达与活性鉴定. 中国兽医科学, 2019, 49(08): 939–946

  (8)高雅, 李平花, 马雪青, 寻广谨, 白兴文, 孙 普, 袁 红, 卢曾军, 刘在新, 李 冬. 口蹄疫病毒衣壳蛋白氨基酸突变对病毒热稳定性的影响. 动物医学进展, 2019, 40(7): 1–8

  (9)王省, 李坤, 卢曾军, 汪肖肖, 谯雨, 刘在新, 曹轶梅. B细胞永生化方法的研究进展. 中国兽医科学, 2018, 48(6): 743–739

  (10)王省, 李坤, 卢曾军, 刘在新, 曹轶梅. B细胞分离方法的研究进展. 中国兽医科学, 2018, 48(8): 1031–1037

  (11)甘利鹏, 张婧, 孙普, 白伟杰, 王治家, 曹轶梅, 李坤, 白兴文, 包慧芳, 李平花, 李冬, 刘在新, 卢曾军. LncRNA TCONS00179042对Marc-145细胞中PRRSV复制的影响. 中国兽医科学, 2018, 48(5): 537–544

  (12)魏国燕, 李坤, 卢曾军, 刘在新, 孙普, 白兴文, 李冬, 陈应理, 包慧芳, 李平花, 付元芳, 张婧, 马雪青, 曹轶梅. 猪C型凝集素受体8A骆驼单域抗体酵母展示文库的构建. 中国兽医学报, 2018, 38(1): 177–182

  (13)李平花, 马雪青, 寻广谨, 白兴文, 孙普, 袁红, 卢曾军, 刘在新. 口蹄疫病毒结构蛋白VP1容忍外源标签的能力. 微生物学报, 2017, 57(5): 659–666

  (14)胡荣, 白伟杰, 王治家, 孙普, 卢曾军, 李冬, 刘在新. 猪繁殖与呼吸综合征病毒NSP2抗原表位区的原核表达及免疫原性分析. 中国畜牧兽医, 2017, 44(6): 1796–1803

  (15)王治家, 张婧, 白伟杰, 孙普, 曹轶梅, 李冬, 刘在新, 卢曾军. 通过基因组合成构建美洲型猪繁殖与呼吸综合征病毒感染性克隆. 中国兽医科学, 2017, 47(07): 838–842

  (16)寻广谨, 李平花, 孙普, 马雪青, 白兴文, 卢曾军, 陈应理, 包慧芳, 李冬, 曹轶梅, 付元芳, 张婧, 刘在新. 针对境外口蹄疫疫情的疫苗储备毒株的构建和生物学特性分析. 中国兽医科学, 2017, 47(08): 988–992

  (17)袁红, 李平花, 袁子文, 白兴文, 孙普, 马雪青, 李坤, 寻广谨, 卢曾军, 包慧芳, 陈应理, 曹轶梅, 付元芳, 张婧, 刘在新. 表达EGFP报告基因口蹄疫病毒亚基因组复制子的构建. 微生物学通报. 2016, 43(8): 1746–1752

  (18)袁红, 李平花, 马雪青, 方先珍, 白兴文, 孙普, 卢曾军, 包慧芳, 曹轶梅, 李冬, 付元芳, 陈应理, 张婧, 刘在新. O型和A型口蹄疫重组标记疫苗病毒株的制备及鉴定. 中国预防兽医学报, 2016, 38(2): 96–100

  (19)白伟杰, 曹轶梅, 包慧芳, 孙普, 付元芳, 李平花, 白兴文, 陈应理, 李坤, 马雪青, 刘在新, 李冬, 卢曾军. 表达FMDV B7多表位基因的重组PRRSV的拯救与复制水平的测定. 中国兽医科学, 2016, 46(04): 449–453

  (20)姜韶东, 李平花, 孙普, 马雪青, 白兴文, 包慧芳, 卢曾军, 曹轶梅, 付元芳, 李冬, 陈应理, 刘在新. 嵌合O/GSLX/CHN/2010株S片段的基因工程口蹄疫病毒的生物学特性. 微生物学通报, 2015, 42(12): 2396–2406

  (21)刘在新. 全球口蹄疫防控技术及病原特性研究概观. 中国农业科学, 2015, 48(17): 3547–3564

  (22)范朋举, 曹轶梅, 卢曾军, 张萌, 孙普, 付元芳, 李平花, 白兴文, 包慧芳, 陈应理, 李冬, 刘在新. 猪细小病毒蛋白主要抗原表位区的原核表达及检测抗体的间接的建立. 中国兽医科学, 2014, 44(09): 902–908

  (23)张萌, 白兴文, 李平花, 范朋举, 包慧芳, 孙普, 卢曾军, 曹轶梅, 陈应理, 刘在新. 口蹄疫病毒O/CHN/Mya98/33-P株前导蛋白对病毒感染性的影响. 微生物学通报, 2014, 41(10): 2052–2060

  (24)张萌, 白兴文, 李平花, 范朋举, 包慧芳, 孙普, 卢曾军, 曹轶梅, 刘在新. 口蹄疫病毒前导蛋白的分子生物学研究进展. 中国动物传染病学报, 2014, 22(1): 73–79

  (25)周春雪, 刘艳红, 李冬, 刘在新, 祁淑芸. 商品化口蹄疫疫苗与猪瘟疫苗对小鼠免疫效力的研究. 中国兽医科学, 2013, 43(06): 572–578

  (26)周春雪, 李冬. TLR-7/8激动剂作为疫苗佐剂的最新研究进展. 免疫学杂志, 2013, 29(06): 527–530

  (27)魏蔚, 白兴文, 包慧芳. 三株重组VP1基因的泛亚1系口蹄疫病毒的蚀斑特性. 中国兽医科学, 2013, 43(08): 795–799

  (28)李艳丽, 曹轶梅, 卢曾军, 孙普, 李平花, 白兴文, 付元芳, 包慧芳, 李冬, 刘在新. N端嵌合口蹄疫病毒中和表位的猪圆环病毒2型衣壳蛋白的表达及其免疫原性. 中国兽医科学, 2013, 43(09): 907–914

  (29)韩成昊, 李平花, 白兴文, 包慧芳, 卢曾军, 孙普, 曹轶梅, 刘在新. 型内非编码区嵌合口蹄疫病毒的拯救及生物学特性分析. 中国兽医科学, 2013, 43(11): 1101–1108

  (30)周春雪, 魏蔚, 李冬, 韩成昊, 李艳丽, 刘在新. Al(OH)3, ISA206和Poly(I:C)免疫佐剂对灭活口蹄疫140S抗原免疫效果影响的研究. 免疫学杂志, 2013, 29(11): 927–932