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Animal Immunogenetics Group


  Animal ImmunogeneticsGroup of Lanzhou Veterinary Research Institute was established in January, 2016 to meet current needs of the development in preventive veterinary medicine. There are four faculty members currently in this group, three of them holding their doctoraldegrees, the otheris a PhD candidate in Hannover Veterinary University, Germany. Human resources also includes 14 postgraduate students, including 2 doctoral candidates and 12 Master Degree students, as well as 5 research assistants. The main research interests of ourgroup arefocusing on the immune responses, regulation and key events during viral infection or vaccination. By using the contemporary theory and techniques in the fields ofmolecular biology, bioinformatics, cell biology, proteomics, immunopathology, and some more, ourgroupaims to analyze the immunoregulation mechanism and pathways in different animals and even different strains within the same species, thus to provide theoretical support for effective prevention and control of animal epidemics. To this end, the following four aspects of researchinterests will be mainly carried out in a long run.

  (1) Antigenic genetics: To comprehensively analyze the polymorphism of major histocompatibility complex molecule classⅠand class Ⅱ(MHCⅠand MHCⅡ) as well as their usage preferenceondifferent alleles of MHCⅡmolecule;To investigate the mechanism of immune tolerance and the intervention strategies.

  (2) Antibody genetics: To reveal the mechanism involved in V-D-J gene rearrangement and allele rejection during the formationof antibody diversity indifferent animals;To investigate the mechanism of receptor gene recombination during B cell differentiation and maturation.

  (3) Immune responsesupon viral infections: To screen high responsive immune response genes(Ir) in different animals and to study the molecular mechanism of Ir genes controlling immune responses; To reveal the mechanism of immune recognition molecules(BCR, TCR and NKCR) undergoing generearrangement and the key factors and pathways of cellular communication during immune recognition;To clarify the functions and pathways of conventional regulatory T cells(cTreg) as well as induced regulatory T cells(iTreg) in regulating antibody formation in animals.

  (4) Mucosal immunology within Porcine intestines: To study the molecular mechanism and factors that influence the class switch recombination from IgM+ B cells to IgA+ B cells during proliferation and differentiation inside theporcinepayer’s patches(PP); To investigate the roles and mechanism of long non-coding RNA and microRNA in regulating the differentiation of T cells and B cells; To develponovel strategies to improve porcine intestinal mucosal immune responses.