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​陈霞

陈霞,女,1990年出生,博士,中国农业科学院兰州兽医研究所优秀博士引进人才。20217月任职口蹄疫与新发病流行病学创新团队助理研究员。20143-20211月兰州大学与上海巴斯德研究所联合培养,20216月博士毕业于兰州大学,主要从事宿主抗病毒免疫应答及非洲猪瘟等DNA病毒获得性免疫机制研究工作。以第一作者(含并列第一)在国际期刊Immunity2020),PLOS Biology2018), The Journal of Immunology2021)等期刊发表高水平论文。先后参与国及合作项目、国家自然科学重点研发项目等,主持国家自然科学青年基金项目。

工作经历

2021-07 至 今, 中国农业科学院兰州兽医研究所, 口蹄疫与新发病流行病学创新团队, 助理研究员

发表论文

1. Chun Zhou1 ; Xia Chen1 ; Rosa Planells-Cases1 ; Jiachen Chu ; Li Wang ; Limin Cao ; Zhihong Li ;Karen I López-Cayuqueo ; Yadong Xie ; Shiwei Ye ; Xiang Wang ; Florian Ullrich ; Shixin Ma ; YiyuanFang ; Xiaoming Zhang ; Zhikang Qian ; Xiaozheng Liang ; Shi-Qing Cai ; Zhengfan Jiang ; Dongming Zhou ; Qibin Leng ; Tsan S Xiao ; Ke Lan ; Jinbo Yang ; Huabin Li ; Chao Peng ; Zhaozhu Qiu ; Thomas J Jentsch ; Hui Xiao ; Transfer of cGAMP into Bystander Cells via LRRC8 Volume-RegulatedAnion Channels Augments STING- Mediated Interferon Responses and Anti-viral Immunity, Immunity, 2020, 52(5): 767-781 IF=22.553

2. . Lei Shi1; Xia Chen1 ; Aip ing Zang ; Tiantian Li ; Yanxiang Hu ; Shixin Ma ; Mengdie Lü ; Huiyong Yin ; Haikun Wang ; Xiaoming Zhang ; Bei Zhang ; Qibin Leng ; Jinbo Yang ; Hui Xiao ; TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis, PLoS Biol, 2019, 17(8) IF=7.07.

3. Xia Chen1 ; Li Wang1 ; Limin Cao ; Tiantian Li ; Zhihong Li ; Yumeng Sun ; Jinqiu Ding ; ChunZhou ; Yadong Xie ; Nan Yue ; Jing Nan ; Xin-Ming Jia ; Chao Peng ; Huabin Li ; Jinbo Yang ; Hui Xiao ; The Regulation of Anion Channel LRRC8 VRACs in Transport of CGAMP and Cisp latin Under Steady-state and Inflammation, The Journal of Imunology, 2021, 206(9): 2061-2074   IF=4.9.

4. Yadong Xie; Yifan Zhao; Lei Shi; Wei Li; Kun Chen; Min Li; Xia Chen ; Haiwei Zhang; Tiantian Li; Yu Matsuzawa Ishimo to ; Xiaomin Yao; Dianhui Shao; Zunfu Ke; Jian Li; Yan Chen; Xiao ming Zhang; Jun Cui; Shuzhong Cui; Qibin Leng; Ken Cadwell; Xiaoxia Li; Hong Wei; Haibing Zhang; Huabin Li; Hui Xiao ; Gutepithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer, The Journal of Clinical Investigation, 2020, 130(4): 2111-2128 IF=14.808

5. Shixin Ma, Xiaoling Wan,Zihou Deng, Lei Shi, Congfang Hao, Zhen yuan Zhou, Chun Zhou, Yiyuan Fang, Jinghua Liu, Jing Yang, Xia Chen, Tian tian Li, Aiping Zang, Shigang Yin, Bin Li, Joel Plumas, Laurence Cha perot, Xao ming Zhang, Guoliang Xu, Lubin Jiang, Nan Shen, Sidong Xiong, Xiaoming Gao, Yan Zhang, and Hui Xiao ; Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs , The Journal of Experimental Medicine (2017) 214 (5): 1471–1491. IF=10.79

近五年主持或参加的国家自然科学基金项目/课题

(1) 国家自然科学基金委员会, 青年科学基金项目, 32202821, 膜通道蛋白VRAC/LRRC8调控非洲猪瘟病毒诱导的宿主免疫应答机制研究, 2023-01-01 2025-12-31, 30万元, 在研, 主持

(2) 国家自然科学基金委员会, 重点项目, 32030040, 阴离子通道LRRC8/VRAC调节cGAMP-STING介导的I型干扰素应答在病毒感染和肿瘤免疫中的作用与机制研究, 2021-01-01 2025-12-31, 295万元, 在研, 参与