王金磊

王金磊，男，1990年2月生，副研究员，中国农业科学院兰州兽医研究所“所级青年英才”。畜禽重要人兽共患病创新团队骨干，主要从事弓形虫病等人兽共患病的重要基因功能和疫苗等相关研究。主持甘肃省杰出青年基金、国家重点研发项目子课题、国家自然科学基金等多项科研课题。以第一或通讯作者在Clin Microbiol Rev、Nat Commun、PLoS Pathog、Trends Parasitol、J Immunol、J Infect Dis、FASEB J等国际期刊上发表SCI论文15多篇。

承担项目

1. 国家自然科学基金青年基金项目：嘌呤转运蛋白NBT1在弓形虫生长繁殖中的作用机制；2019.01-2021.12（主持）

2. 国家重点研发计划-项目子课题：动物重要寄生虫的生长发育与寄生机制；2022.11-2025.12（主持）

3. 甘肃省自然科学基金-杰出青年基金：弓形虫GRA56调控小分子物质在宿主细胞和纳虫泡之间转运的作用机制；2023.07-2026.06（主持）

4. 甘肃省联合科研基金-重点项目：弓形虫关键生长发育因子的鉴定及功能解析；2023.10-2026.09（主持）

代表论文与著作

1. Wang JL, Li TT, Zhang NZ, Wang M, Sun LX, Zhang ZW, Fu BQ, Elsheikha HM, Zhu XQ. The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony. Nat Commun. 2024;15(1):793.

2. Wang JL, Li TT, Elsheikha HM, Liang QL, Zhang ZW, Wang M, Sibley LD, Zhu XQ. The protein phosphatase 2A holoenzyme is a key regulator of starch metabolism and bradyzoite differentiation in Toxoplasma gondii. Nat Commun. 2022;13(1):7560.

3. Liang QL, Nie LB, Elsheikha HM, Li TT, Sun LX, Zhang ZW, Wang M, Fu BQ, Zhu XQ, Wang JL. The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence. PLoS Pathog. 2023;19(12):e1011831.

4. Li TT, Zhao DY, Liang QL, Elsheikha HM, Wang M, Sun LX, Zhang ZW, Chen XQ, Zhu XQ, Wang JL. The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii. FASEB J. 2023;37(6):e22932.

5. Zheng XN, Sun LX, Elsheikha HM, Li TT, Gao J, Wu XJ, Zhang ZW, Wang M, Fu BQ, Zhu XQ, Wang JL. A newly characterized dense granule protein (GRA76) is important for the growth and virulence of Toxoplasma gondii. Int J Parasitol. 2024;54(2):109-121.

6. Wang JL, Liang QL, Li TT, He JJ, Bai MJ, Cao XZ, Elsheikha HM, Zhu XQ. Toxoplasma gondii tkl1 deletion mutant is a promising vaccine against acute, chronic, and congenital toxoplasmosis in mice. J Immunol. 2020;204(6):1562-1570.

7. Wang JL, Bai MJ, Elsheikha HM, Liang QL, Li TT, Cao XZ, Zhu XQ. Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection. FASEB J. 2020;34(2):3165-3178.

8. Wang JL, Zhang NZ, Li TT, He JJ, Elsheikha HM, Zhu XQ. Advances in the development of anti-Toxoplasma gondii vaccines: challenges, opportunities, and perspectives. Trends Parasitol. 2019;35(3):239-253.

9. Wang JL, Li TT, Elsheikha HM, Chen K, Cong W, Yang WB, Bai MJ, Huang SY, Zhu XQ. Live attenuated Pru:Δcdpk2 strain of Toxoplasma gondii protects against acute, chronic, and congenital toxoplasmosis. J Infect Dis. 2018;218(5):768-777.

10. Wang JL, Li TT, Liu GH, Zhu XQ, Yao C. Two tales of Cytauxzoon felis infections in domestic cats. Clin Microbiol Rev. 2017;30(4):861-885.

联系方式：18518223593，wangjinlei90@126.com