学术报告通知
报告题目:结构生物学在药物筛选中的应用
报告人:Jingxian Liu研究员
报告时间和地点:2016年6月17日下午2:30,国家重点实验室三楼会议室
个人简介:
刘敬贤,上海睿智化学有限公司高级研究员,生物大分子结构生物学组长。2009年1月~2009年7月,在南洋理工大学从事博士后研究工作,研究方向为蛋白表达,纯化和X射线晶体结构分析,2009年8月~ 2014年2月,在新加坡科技研究局从事博士后研究工作,主要研究方向为蛋白结构解析、辅助疫苗设计等。2014年2月~2014年10月,担任上海睿智化学有限公司高级研究员,2014年10月至今,担任上海睿智化学有限公司生物大分子结构生物学组长。
发表文章:
Liu J, Xiao Z, Ko H, Shen M, Ren E. Activating killer cell immunoglobulin-like receptor 2DS2 binds to HLA-A*11. P.N.A.S. published ahead of print February 3, 2014, doi:10.1073/pnas.1322052111
Joanna Ai Ling Choo #, Liu J#, Xinyu Toh, Gijsbert M. Grotenbreg, Ee Chee Ren. The immunodominant Influenza A virus M158-66 CTL epitope exhibits degenerate class I MHC restriction in humans. J Virol. 2014 Sep 15;88(18):10613-23. doi: 10.1128/JVI.00855-14. Epub 2014 Jul 2. (# co-first)
Liu J, Chen Y, Ren E. Crystal structures of Hepatitis B virus core 18-27 peptide bound to multiple HLA-A2 alleles: implications for therapeutic vaccine design. European Journal of Immunology 2011 July.
Liu J, Song J. Insights into protein aggregation by NMR characterization of insoluble SH3 mutants solubilized in salt-free water.
PLoS One. 2009 Nov 23;4(11):e7805.
Liu J, Song J. NMR Evidence for Forming Highly-Populated Helical Conformations in the Partially-Folded hNck2 SH3 Domain. Biophysical Journal. 2008 July 3.
Liu J, Song J. A novel nucleolar transcriptional activator ApLLP for long-term memory formation is intrinsically unstructured but functionally active. Biochem Biophys Res Commun. 2008 Feb 8;366(2):585-91. Epub 2007 Dec 17.
PMID: 18078811
Liu J, Li M, Ran X, Fan JS, Song J.
Structural insight into the binding diversity between the human Nck2 SH3 domains and proline-rich proteins. Biochemistry. 2006 Jun 13;45(23):7171-84.
PMID: 16752908
Li M, Liu J, Ran X, Fang M, Shi J, Qin H, Goh JM, Song J.
Resurrecting abandoned proteins with pure water: CD and NMR studies of protein fragments solubilized in salt-free water.
Biophys J. 2006 Dec 1;91(11):4201-9. Epub 2006 Sep 15.
PMID: 16980357
Li M, Liu J, Song J.
Nogo goes in the pure water: solution structure of Nogo-60 and design of the structured and buffer-soluble Nogo-54 for enhancing CNS regeneration.
Protein Sci. 2006 Aug;15(8):1835-41.
PMID: 16877707
Ran X, Qin H, Liu J, Fan JS, Shi J, Song J.
NMR structure and dynamics of human ephrin-B2 ectodomain: the functionally critical C-D and G-H loops are highly dynamic in solution.
Proteins. 2008 Aug 15;72(3):1019-29.
PMID: 1830022
科技管理处/兽用纳米材料与应用培育团队
2016年6月16日