王锦明，男，山西临县人，所聘研究员，中国农业科学院兰州兽医研究所“青年英才计划”入选者，外寄生虫与虫媒疫病创新团队骨干。2017年7月入职中国农业科学院兰州兽医研究所，从事梨形虫与蜱互作生物信息学、流行病学、防控技术、梨形虫发育调控与传播机制研究。以第一作者在Plos Pathogens、BMC Biology、Emerging Microbe Infection、International Journal for Parasitology、FASEB Journal等主流期刊上发表SCI论文16篇；担任Frontiers in Parasitology 编委；Emerging Microbes Infections、Transboundary and Emerging Diseases、International Journal of Infectious Diseases、Frontiers in Microbiology、Infectious Diseases of Poverty、Genomics等杂志审稿人。以第一人发明人获得国家发明专利4项。

一、科研项目（主持）：

1.国家自然科学基金面上项目“球状体蛋白1促进巴贝斯虫入侵宿主红细胞的分子机制”（32573390，50万，2026年1月-2029年12月）

2.十四五国家重点研发计划项目“动物重要虫媒疫病流行传播机制与防控技术研发”子课题（2024YFD1800100, 60万，2024年12月-2027年12月）；

3.甘肃省联合科研基金重点项目“调控巴贝斯虫配子母细胞形成发育的关键分子鉴定及功能研究”（24JRRA812, 50万元，2024年10月-2027年10月）；

4.青年英才计划人才启动项目（200万, 2024年03月-2029年03月）；

5.动物疫病防控全国重点实验室重大成果培育（30万，2023年01月-2024年12月）；

6.十四五国家重点研发计划项目子课题“重要寄生虫发育调控”（2022YFD1800200，81万，2022年12月-2025年12月）；

7.甘肃省自然科学基金（22JR5RA031，6万，2021年10月-2024年10月）。

二、代表性论文：

1.Wang J, Chai Y, Ye Y, Yang J, Zhang X, Yin H, Guan G. Comparative genomics, integrated with single-cell sequencing and genetic analyses, reveal roles of transcription factor AP2-M2 in asexual replication of Babesia parasite. PLoS Pathog. 2025 Nov 13;21(11):e1013699. 

2. Jinming Wang1,2,a,*, Yijun Chai1,2,a, Jifei Yang1,2, Yuxin Ye1,2, Jianxun Luo1,2, Hong Yin1,2,3, Guiquan Guan1,2*. Dissecting the role of transcription factor AP2-M in Babesia asexual replication. 2024 Oct 31;38(20):e70119.

3. Wang J(共一兼通讯), Chai Y(共一), Yang J, Chen K, Liu G, Luo J, Guan G, Ren Q, Yin H. Insight into Hyalomma anatolicum biology by comparative genomics analyses. Int J Parasitol. 2024 Mar;54(3-4):157-170.

4. Wang J(共一兼通讯), Chen K(共一), Ren Q, Zhang S, Yang J, Wang Y, Nian Y, Li X, Liu G, Luo J, Yin H, Guan G. Comparative genomics reveals unique features of two Babesia motasi subspecies: Babesia motasi lintanensis and Babesia motasi hebeiensis. Int J Parasitol. 2023 May;53(5-6):265-283.

5. Wang Y, Zhang S, Li X, Nian Y, Liu X, Liu J, Yin H(共通讯), Guan G(共通讯), Wang J(共通讯). A high-resolution melting approach for the simultaneous differentiation of five human babesiosis-causing Babesia species. Parasit Vectors. 2023 Aug 28;16(1):299. doi: 10.1186/s13071-023-05839-5.

6. Zhang S(共一), Wang J(共一), Li X, Wang Y, Nian Y, You C, Zhang D, Guan G. Babeisa duncani infection alters gut microbiota profile in hamsters. Parasites Hosts Dis. 2023 Feb;61(1):42-52.

7. Wang J(共一), Chen K(共一), Yang J, Zhang S, Li Y, Liu G, Luo J, Yin H, Wang G, Guan G. Comparative genomic analysis of Babesia duncani responsible for human babesiosis. BMC Biol. 2022 Jul 5;20(1):153. doi: 10.1186/s12915-022-01361-9.

8. Wang J, Chen K, Ren Q, Zhang Y, Liu J, Wang G, Liu A, Li Y, Liu G, Luo J, Miao W, Xiong J, Yin H, Guan G. Systematic Comparison of the Performances of De Novo Genome Assemblers for Oxford Nanopore Technology Reads From Piroplasm. Front Cell Infect Microbiol. 2021 Aug 16;11:696669. 

9. Wang J(共一), Wang X(共一), Guan G, Yang J, Liu J, Liu A, Li Y, Luo J, Yin H. Stable transfection system for Babesia sp. Xinjiang. Parasit Vectors. 2021 Sep 9;14(1):463. 

10. Wang X(共一), Wang J(共一), Liu J, Yang J, Lv Z, Liu A, Li Y, Li Y, Lan H, Liu G, Luo J, Guan G, Yin H. Establishment of a transient transfection system for Babesia sp. Xinjiang using homologous promoters. Parasitol Res. 2021 Oct;120(10):3625-3630.

11. Xu J, Wang J, Li Z, He X, Zhao S, Ma Q, Li X, Liu J, Liu A, Li Y, Yin H, Luo J, Guan G. A universal ELISA assay for detecting six strains of ovine Babesia species in China. Vet Parasitol. 2021,300:109616.

12. Wang J, Yang J, Gao S, Wang X, Sun H, Lv Z, Li Y, Liu A, Liu J, Luo J, Guan G, Yin H. Genetic Diversity of Babesia bovis MSA-1, MSA-2b and MSA-2c in China. Pathogens. 2020 Jun 15;9(6):473.

13. Wang J, Gao S, Zhang S, He X, Liu J, Liu A, Li Y, Liu G, Luo J, Guan G, Yin H. Rapid detection of Babesia motasi responsible for human babesiosis by cross-priming amplification combined with a vertical flow. Parasit Vectors. 2020 Jul 29;13(1):377.

14. Wang J, Yang J, Gao S, Liu A, Rashid M, Li Y, Liu Z, Liu J, Liu G, Luo J, Guan G, Yin H. Rapid detection and differentiation of Theileria annulata, T. orientalis and T. sinensis using high-resolution melting analysis. Ticks Tick Borne Dis. 2020 Jan;11(1):101312.

15. Wang J, Wang X, Sun H, Lv Z, Li Y, Luo J, Guan G, Yin H. Molecular evidence of piroplasm infection in companion animals in Hunan Province, China. BMC Vet Res. 2020 Aug 17;16(1):297.

16. Wang X, Wang J, Liu J, Liu A, He X, Xiang Q, Li Y, Yin H, Luo J, Guan G. Insights into the phylogenetic relationships and drug targets of Babesia isolates infective to small ruminants from the mitochondrial genomes. Parasit Vectors. 2020 Jul 29;13(1):378. 

17. Wang J, Zhang S, Yang J, Liu J, Zhang D, Li Y, Luo J, Guan G, Yin H. Babesia divergens in human in Gansu province, China. Emerg Microbes Infect. 2019;8(1):959-961.

18. Wang J, Liu J, Yang J, Wang X, Li Z, Jianlin X, Li X, Xiang Q, Li Y, Liu Z, Luo J, Guan G, Yin H. The first molecular detection and genetic diversity of Babesia caballi and Theileria equi in horses of Gansu province, China. Ticks Tick Borne Dis. 2019 Apr;10(3):528-532.

19. Wang J, Liu A, Zhang S, Gao S, Rashid M, Li Y, Liu J, Ma Q, Li Z, Liu Z, Luo J, Guan G, Yin H. High resolution melting analysis of the 18S rRNA gene for the rapid diagnosis of bovine babesiosis. Parasit Vectors. 2019 Nov 6;12(1):523.

20. Wang J, Liu J, Yang J, Liu Z, Wang X, Li Y, Luo J, Guan G, Yin H. Molecular detection and genetic diversity of Babesia canis canis in pet dogs in Henan Province, China. Parasitol Int. 2019 Aug;71:37-40.

21. Wang X, Wang J, Liu J, Liu A, He X, Xu J, Li Z, Zhao S, Li Y, Yin H, Luo J, Guan G. Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China. Parasit Vectors. 2019 Jun 24;12(1):312.

22. Wang J, Yang J, Liu J, Wang X, Xu J, Liu A, Li Y, Liu Z, Ren Q, Luo J, Guan G, Yin H. Molecular detection and genetic diversity of Theileria orientalis in cattle in China. Parasitol Res. 2018 Dec;117(12):3689-3694.

三、联系方式：

手机：15593193566

Email：wjm0403@caas.cn

通讯地址：甘肃省兰州市城关区盐场路徐家坪1号（邮编 730046）