科研成果

SCI论文清单（2017年以来）

2020年：

1.Yang Li#, Ning Yang#, Jianing Chen, Xin Huang, Na Zhang, Shanshan Yang, Guo Liu, Guangliang Liu*. Next-generation porcine intestinal organoids: an apical-out organoid model for swine enteric virus infection and immune response investigations. Journal of Virology, 2020, 94(21): DOI: 10.1128/JVI.01006-20 (IF: 4.501)

2.Guo Liu, Bin Wang, Qingbo Chen, Yang Li, Baoyu Li, Ning Yang, Shanshan Yang, Guanglliang Liu*. Interleukin (IL)-21 Promotes the Differentiation of IgA-Producing Plasma Cells in Porcine Peyer's Patches via the JAK-STAT Signaling Pathway. Frontiers in Immunology, 2020, 11: 1303. DOI: 10.3389/fimmu.2020.01303. (IF=5.015)

3.Shanshan Yang, Yang Li, Bin Wang, Ning Yang, Xin Huang, Qingbo, Chen, Shuxian Geng, Yawei Zhou, Han Shi, Leyi Wang, Sylvia Brugman, Huub Savelkoul, Guangliang Liu*. Acute porcine epidemic diarrhea virus infection reshapes the intestinal microbiota, 2020, Virology, 548(9), 200-212. (IF: 2.819)

4.Jianing Chen, Li Jin, Zemei Wang, Liyuan Wang, Qingbo Chen, Yaru Cui, Guangliang Liu*. N6-methyladenosine regulates PEDV replication and host gene expression. Virology. 2020, 548: 59–72. (IF=2.819)

5.Miaomiao Yan#, Jingling Huang#, Jianing Chen, Wenting Yang, Guangliang Liu*. Preparation, identification, and functional analysis of monoclonal antibodies against atypical porcine pestivirus NS3 protein. Journal of Veterinary Diagnostic Investigation, 2020, DOI10.1177/10406387209399. (IF=1.135)

6.Yuguang Fu, Baoyu Li, Guanglaing Liu*. Rapid and efficient detection methods of pathogenic swine enteric coronaviruses. Applied Microbiology and Biotechnology. 2020, 104(14): 6091-6100. (IF=3.53)

7.Guangming Ding#, Yuguang Fu#, Baoyu Li, Jianing Chen, Jianling Wang, Baishuang Yin, Wangli Sha, Guanglaing Liu*. Development of a multiplex RT-PCR for the detection of major diarrhoeal viruses in pig herds in China. Transboundary Emerging Diseases. 2020, 67(2):678-685. (IF=4.188)

8.Shunli Yang, Li Yuan, Youjun Shang, Jinyan Wu, Xiangtao Liu, Jie Zhang, Zygmunt Pejsak, Katarzyna Podgórska, Katarzyna Stepniewska, Muhammad Umar Zafar Khan, Jianping Cai, Shuanghui Yin. Selection and Characterization of CSFV-Specific Single-Domain Antibodies and Their Application along with Immunomagnetic Nanobeads and Quantum Dots. Biomed Research International, 2020:3201630. (IF=2.276)

2019年：

9.Xin Huang, Jianing Chen, Gang Yao, Qingyong Guo, Jinquan Wang, Guangliang Liu*. A TaqMan-probe-based multiplex real-time RT-qPCR for simultaneous detection of porcine enteric coronaviruses. Applied Microbiology and Biotechnology. 2019, 103(12): 4943-4952. (IF=3.67)

10.Jianing Chen, Li Jin, Miaomiao Yan, Ze Yang, Haiwen Wang, Shuxian Geng, Zhenli Gong, Guangliang Liu*. Serum Exosomes from Newborn Piglets Restrict Porcine Epidemic Diarrhea Virus Infection. Journal of Proteome Research. 2019, 18(5):1939-1947. (IF=3.78)

11.Wenting Yang#, Wenwen Chen#, Jingling Huang, Li Jin, Yawei Zhou, Jianing Chen, Na Zhang, Donglai Wu, Encheng Sun, Guanglaing Liu*. Generation, identification, and functional analysis of monoclonal antibodies against porcine epidemic diarrhea virus nucleocapsid. Applied Microbiology and Biotechnology. 2019, 103(9): 3705-3714. (IF=3.67)

12.Yuguang Fu, Ralf Dürrwald, Fandan Meng, Jie Tong, Nai-Huei Wu, Ang Su, Xiangping Yin, Ludwig Haas, Michaela Schmidtke, Roland Zell, Andi Krumbholz, Georg Herrler. Infection studies in pigs and porcine airway epithelial cells reveal an evolution of A(H1N1)pdm09 influenza A viruses toward lower Virulence. Journal of Infectious Diseases. 2019, 219(10):1596-1604. (IF=5.186)

13.Guangliang Liu, Fangfang Zhang, Ruixue Wang, Steve London, Lucille London*. Salivary gland immunization via Wharton's duct activates differential T-cell responses within the salivary gland immune system. FASEB Journal. 2019, 33(5):6011-6022. (IF=5.391)

14.Jianing Chen, Haiwen Wang, Li Jin, Liyuan Wang, Xin Huang, Wenwen Chen, Miaomiao Yan, Guanlgiang Liu*. Profile analysis of circRNAs induced by porcine endemic diarrhea virus infection in porcine intestinal epithelial cells. Virology. 2019, 527:169-179. (IF=2.657)

15.Jianing Chen, Chengyu Zhang, Na Zhang, Guangliang Liu*. Porcine endemic diarrhea virus infection regulates long noncoding RNA expression. Virology. 2019, 527: 89-97. (IF=2.657)

16.Shunli Yang, Baohong Liu, Shuanghui Yin, Youjun Shang, Xinming Zhang, Muhammad Umar Zafar Khan, Xiangtao Liu, Jianping Cai. Porcine Circovirus Type 2 Induces Single Immunoglobulin Interleukin-1 Related Receptor (SIGIRR) Downregulation to Promote Interleukin-1β Upregulation in Porcine Alveolar Macrophage. Viruses. 2019, 11(11): 1021 (IF=3.811)

17.Zigang Qu, Wenhui Li, Nianzhang Zhang, Li Li, Hongbin Yan, Tingting Li, Jianmin Cui, Yang Yang, Wanzhong Jia, Baoquan Fu Comparative Genomic Analysis of Trichinella spiralis Reveals Potential Mechanisms of Adaptive Evolution. Biomed Research International. 2019: 2948973. (IF=2.197)

18.Xingxing Xiao, Kun Li, Xueting Ma, Baohong Liu, Xueyang He, Shunli Yang, Wenqing Wang, Baoyu Jiang, Jianping Cai. Mucosal-Associated Invariant T Cells Expressing the TRAV1-TRAJ33 Chain Are Present in Pigs. Frontiers in Immunology. 2019, 10:2070. (IF=4.716)

19.Xingxing Xiao, Baohong Liu, Xueting Ma, Shunli Yang, Jianping Cai. Molecular cloning and characterization of the pig MHC class Ⅰ-related MR1 gene. Developmental and Comparative Immunology. 2019, 96: 58-67. (IF=3.119)

2018年：

20.Yuguang Fu, Jie Tong, Fandan Meng, Hoeltig D, Guangliang Liu, Xiangping Yin, Georg Herrler*. Ciliostasis of airway epithelial cells facilitates influenza A virus infection. Veterinary Research. 2018, 49(1):65. (IF=2.903)

21.Shunli Yang, Li Li, Shuanghui Yin, Youjun Shang, Muhammad Umar Zafar Khan, Xueyang He, Li Yuan, Xue Gao, Xiangtao Liu, Jianping Cai. Single-domain antibodies as promising experimental tools in imaging and isolation of porcine epidemic diarrhea virus. Applied Microbiology and Biotechnology. 2018, 102(20): 8931-8942. (IF=3.34)

2017年：

22.Jianing Chen, Chengyu Zhang, Yue Liu, Guangliang Liu*. Super-oxidized water inactivates major viruses circulating in swine farms. Journal of Virolological Methods. 2017, 242:27-29. (IF=1.693)

23.Zhenxing Gong, Hao Yin, Xueting Ma, Baohong Liu, Zhenglan Han, Lingqiao Gou, Jianping Cai. Widespread 5-methylcytosine in the genomes of avian Coccidia and other apicomplexan parasites detected by an ELISA-based method. Parasitology Research. 2017, 116(5): 1573-1579. (IF=2.329)

24.Xingxing Xiao, Jianping Cai J. Mucosal-Associated Invariant T Cells: New Insights into Antigen Recognition and Activation. Frontiers in Immunology. 2017, 8:1540. (IF=6.429)

（注：#为同等贡献；*为通讯作者）

 

已授权国家发明专利

序号	专利名称	专利号	主要发明人
1	检测猪圆环病毒2型IgM抗体ELISA的试剂盒及检测方法	ZL201711011298.6	杨顺利
2	一种定量检测猪瘟病毒IgG抗体竞争ELISA试剂盒及其检测方法	ZL201710301443.8	杨顺利；尹双辉；尚佑军；袁莉；吴锦艳；蔡建平；刘湘涛
3	一种猪瘟病毒血清总抗体固体相阻断ELISA试剂盒所用抗原的制备方法	ZL201710303456.9	尹双辉；杨顺利；尚佑军；吴锦艳；袁莉；刘湘涛；蔡建平
4	一种猪病毒性传染病血清IgG抗体多重ELISA检测试剂盒及其检测方法	ZL201710301560.4	尹双辉；杨顺利；蔡建平；尚佑军；袁莉
5	一种用于猪病毒性腹泻病毒5重RT-PCR检测试剂盒	ZL201610017707.2	刘光亮；李宝玉；付钰广；陈佳宁；兰喜；丁光明
6	一种猪流行性腹泻病毒M蛋白特异性重链抗体	ZL201510985596.X	尹双辉；杨顺利；尚佑军；蔡建平；刘湘涛
7	一种无外源菌DNA污染的球虫卵囊的制备方法	ZL201510642944.3	龚振兴；蔡建平；刘保红；殷昊；李法财；马雪婷
8	一种鸭坦布苏病毒抗体固相竞争ELISA检测试剂盒	ZL201310009747.9	朱启运；付钰广；吉艳红
9	一种鸭坦布苏病毒检测试剂盒	ZL201210267345.4	朱启运；付钰广；刘宗梁；吉艳红；郭建宏
10	鸡主要组织相容性复合体/肽四聚体的构建方法及其产品	ZL200710152068.1	吴东来；刘光亮；王群；肖一红等

竞争性科研项目
序号	项目名称	来源	编号	主持人	起止年限	经费(万元)
1	PEDV感染通过诱生肠道微环境TGF-β1促进B细胞凋亡的分子机制	国家自然基金面上项目	31972689	刘光亮	2020-2023	59
2	利用猪肠道派伊尔淋巴结精准切片体外培养体系研究PEDV感染与肠道黏膜免疫应答	基本科研业务费	1610312020002	付钰广	2020-2022	30
3	猪肠道类器官3D培养系统的建立及其在PEDV感染及免疫应答研究中的应用	基本科研业务费	1610312020020	刘光亮	2020-2022	90
4	NOD2调控PEDV免疫应答的分子机制研究	甘肃省青年科技人才托举工程		陈佳宁	2019-2020	5
5	酒石酸泰万菌素对PRRSV复制的影响	中牧合作		刘光亮	2018	10
6	NOD2调控PEDV免疫应答的分子机制研究	青年科学基金项目	31702209	陈佳宁	2018-2020	27
7	球虫子孢子细胞表面蛋白谱鉴定及主要表面蛋白免疫原性研究	甘肃省科技厅青年基金	18JR3RA401	曲自刚	2018-2020	3
8	胞内寄生原虫与宿主细胞相互作用网络及作用机制	国家重点研发计划	2017YFD0500403	蔡建平	2017-2021	314
9	动物原虫病诊断与检测新技术的研究	国家重点研发计划	2017YFD0501204	曲自刚	2017-2021	30
10	SIGIRR调控PCV2感染猪肺泡巨噬细胞炎性细胞因子表达的机制研究	国家自然科学基金	31602085	杨顺利	2017-2019	24
11	猪消化道传染病新型防控策略的研发	人社部“中国留学人员回国创业启动支持计划创新子项目”		刘光亮	2017	3
12	猪流行性腹泻病毒黏膜免疫发生与调控机制	国家重点研发计划	2016YFD0500103	刘光亮	2016-2020	140
13	猪流行性腹泻病毒诱导T细胞依赖的sIgA+ B细胞分化机制	国家自然基金面上项目	31572498	刘光亮	2016-2019	76.4
14	“青年英才计划”择优支持启动基金	中国农业科学院		刘光亮	2015-2019	300
15	猪病毒性腹泻分子鉴别诊断方法的建立	中央公益事业单位科研事业费		刘光亮	2015	30
16	猪消化道疫病高效免疫防控策略的平台建设	中国农业科学院		刘光亮	2015	20
17	猪病毒性腹泻病快速诊断技术与防控策略的研发	中农威特生物公司横向合作		刘光亮	2014-2016	170
18	柔嫩艾美尔球虫组蛋白乙酰化酶3的生化特性及其药靶有效性研究	国家自然科学基金	39970565	殷昊	2014-2016	24
19	“家禽主要细菌病防控技术研究与示范”子课题--鸡坏死性肠炎防控技术研究与示范	公益性行业（农业）科研专项经费项目	201303044	蔡建平	2013-2017	64
20	组蛋白修饰和DNA甲基化对球虫发育阶段转化和早熟发育的调控机理研究	国家自然基金面上项目	31272554	蔡建平	2013-2016	83